Ĭhronis-Tuscano A, Wang CH, Strickland J, Almirall D, Stein MA (2016) Personalized treatment of mothers with ADHD and their young at-risk children: a SMART pilot. Ĭheung YK, Chakraborty B, Davidson KW (2015) Sequential multiple assignment randomized trial (SMART) with adaptive randomization for quality improvement in depression treatment program: SMART with adaptive randomization. Ĭhakraborty B, Moodie EEM (2013) Statistical Methods for Dynamic Treatment Regimes. Ĭable N, Sacker A (2007) Typologies of alcohol consumption in adolescence: predictors and adult outcomes. Īugust GJ, Piehler TF, Bloomquist ML (2016) Being ‘SMART’ about adolescent conduct problems prevention: executing a SMART pilot study in a juvenile diversion agency. Springer International Publishing, Cham, pp 89–120. In: Collins LM, Kugler KC (eds) Optimization of behavioral, biobehavioral, and biomedical interventions: advanced topics, Statistics for social and behavioral sciences. Īlmirall D, Nahum-Shani I, Lu W, Kasari C (2018) Experimental designs for research on adaptive interventions: singly and sequentially randomized trials. KeywordsĪlmirall D, DiStefano C, Chang Y-C, Shire S, Kaiser A, Lu X, Nahum-Shani I, Landa R, Mathy P, Kasari C (2016) “Longitudinal Effects of Adaptive Interventions With a Speech-Generating Device in Minimally Verbal Children With ASD.” J Clin Child Adolesc 45 (4): 442–56. To illustrate ideas, we discuss the design of a SMART used to answer critical questions in the development of a DTR for individuals diagnosed with alcohol use disorder. This chapter provides an introduction to DTRs, common types of scientific questions researchers may have concerning the development of a highly effective DTR, and how SMARTs can be used to address such questions. Sequential, multiple assignment, randomized trials (SMARTs) are a type of experimental design that can be used to build effective dynamic treatment regimens (DTRs). This includes decisions concerning how to begin treatment based on a patient’s characteristics at entry, as well as how to tailor treatment over time based on the patient’s changing needs. A dynamic treatment regimen (DTR) is a prespecified set of decision rules that can be used to guide important clinical decisions about treatment planning.
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